Zycortal For Dogs Side Effects

For use as replacement therapy for mineralocorticoid deficiency in dogs with primary hypoadrenocorticism addison s disease.

Zycortal for dogs side effects.

Zycortal is a new treatment for addison s disease hypoadrenocorticism in dogs. In a laboratory study zycortal suspension was administered via subcutaneous injection to 32 beagle dogs four groups of 8 dogs each at doses of 0 1 3 and 5 times the labeled starting dose 1x 2 2 mg kg once every 21 days for 6 months for a total of 9 injections. One hundred thirteen 113 dogs were treated with zycortal suspension and 39 dogs were treated with the active control. Refer to the prescribing information for complete details.

One hundred thirteen 113 dogs were treated with zycortal suspension and 39 dogs were treated with the active control. Excessive weight gain may indicate fluid retention secondary to sodium retention. Possible side effects of zycortal suspension include polyuria excessive urination polydipsia excessive thirst increased blood volume edema and cardiac enlargement. The most common side effects with zycortal which may affect more than 1 in 10 dogs are polydipsia increase in water intake and polyuria increase in urine production.

Like other adrenocortical hormones percorten v may cause severe side effects if dosage is too high or prolonged. Both groups were administered an initial dose of 2 2 mg kg. Some patients are more sensitive to the actions of zycortal suspension and may exhibit side effects in an exaggerated degree. Dogs presenting in addisonian crisis must be rehydrated with appropriate intravenous therapy before starting treatment with zycortal suspension.

It is given by injection at approximately 1 month intervals. Subsequent doses administered and or frequency. One hundred fifty two 152 dogs of various breeds 0 5 12 4 years of age and weighing 2 1 134 6 lbs 0 95 61 2 kg were enrolled. Do not use in pregnant dogs or in dogs suffering from congestive heart disease severe renal disease or edema.

Zycortal suspension replaces mineralocorticoids which are deficient in dogs with addison s. Zycortal suspension should be used with caution in dogs with congestive heart disease edema severe renal disease or primary hepatic failure. Do not use in pregnant dogs or in dogs suffering from congestive heart failure severe renal disease or edema. Both groups were administered an initial dose of 2 2 mg kg.

Reduce dosage in dogs showing signs of hypernatremia or hypokalemia.